Opportunity Information: Apply for PA 24 185
The Mentored Patient-Oriented Research Career Development Award (K23) is an NIH career development grant designed to help early-stage clinician-researchers build the skills, experience, and publication record needed to become independent investigators in patient-oriented research. It is specifically geared toward individuals who hold a clinical doctoral degree and have made a clear commitment to conducting research that directly involves human participants or uses human-derived data and materials in ways that are meaningfully tied to patient care and clinical outcomes. The core idea is protected, structured time for mentored research and career development so that a clinician can transition from a mentored phase into an independent research career focused on improving health through studies grounded in patient interaction and clinically relevant questions.
This particular parent announcement is labeled "Independent Clinical Trial Not Allowed," which signals an important boundary for applicants planning their research activities. In practical terms, the proposed K23 research plan cannot be built around an independently led clinical trial by the candidate as the primary driver of the award. The mechanism is meant to support mentored development in patient-oriented research without positioning the applicant as the independent sponsor/leader of a clinical trial within the K23. Applicants typically need to ensure their project fits NIH rules for this funding opportunity and aligns with any additional institute- or center-specific guidance, especially if there are any interventional components, ancillary studies, or involvement with an existing trial.
The sponsoring agency is the National Institutes of Health (NIH), and the funding instrument is a discretionary grant under a broad set of health-related assistance listings (multiple CFDA numbers are associated with the parent mechanism because many NIH institutes participate). The opportunity is listed as PA-24-185, created on April 9, 2024, and it remains open with an original closing date of May 7, 2027. While the posting includes an "Award Ceiling" field, no specific ceiling amount is stated in the provided source text, and the number of expected awards is not specified here either, which is common for parent NIH announcements because actual award counts and budgets can vary by institute, fiscal year, and application pressure.
Eligibility is expansive at the organizational level and includes many standard U.S. applicant types such as state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, there are clear limits related to foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning certain types of internationally performed activities may be permissible when they meet NIH policy requirements and are justified within the scope of an otherwise eligible U.S.-based application.
Overall, this opportunity is best understood as a mentored career development pathway for clinically trained professionals who want to specialize in patient-oriented research, with the award structured to provide mentorship, training, and research support while the candidate develops into an independent clinician-scientist. The emphasis is on building a strong, supervised research trajectory in clinical or patient-centered research settings, rather than launching an independently run clinical trial as the central feature of the award.Apply for PA 24 185
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.310, 93.313, 93.361, 93.837, 93.838, 93.839, 93.840, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866.
- This funding opportunity was created on 2024-04-09.
- Applicants must submit their applications by 2027-05-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Mentored Patient-Oriented Research Career Development Award (K23) (PA-24-185)
What is the Mentored Patient-Oriented Research Career Development Award (K23)?
The K23 is an NIH career development grant intended to help early-stage clinician-researchers gain the skills, experience, and publication record needed to become independent investigators in patient-oriented research. A central feature is protected, structured time for mentored research and career development so the candidate can transition from a mentored phase into an independent research career.
Who is this K23 opportunity designed for?
This opportunity is geared toward individuals who hold a clinical doctoral degree and who have made a clear commitment to conducting patient-oriented research. The focus is on clinician-researchers building toward independence through mentorship, training, and a clinically relevant research plan.
What does "patient-oriented research" mean in this context?
In this announcement, patient-oriented research refers to research that directly involves human participants or uses human-derived data and materials in ways that are meaningfully tied to patient care and clinical outcomes. The work is grounded in patient interaction and clinically relevant questions aimed at improving health.
What does "Independent Clinical Trial Not Allowed" mean for this announcement?
"Independent Clinical Trial Not Allowed" sets an important boundary: the proposed K23 research plan cannot be built around an independently led clinical trial by the candidate as the primary driver of the award. The mechanism supports mentored development in patient-oriented research without positioning the applicant as the independent sponsor or leader of a clinical trial within the K23.
Can the K23 project include any interventional or trial-related activities?
The information provided emphasizes that applicants should ensure the project fits NIH rules for this funding opportunity and aligns with institute- or center-specific guidance, particularly if there are interventional components, ancillary studies, or involvement with an existing trial. The key constraint described is that the award cannot be centered on an independently led clinical trial by the candidate.
What is the main purpose of the K23 mechanism?
The core purpose is to provide protected, structured time for mentored research and career development. The intent is to build a strong, supervised research trajectory in clinical or patient-centered research settings and support a transition to an independent research career.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the funding instrument for this opportunity?
The funding instrument is a discretionary grant.
What is the opportunity number and title information provided?
The opportunity is listed as PA-24-185 and is described as the Mentored Patient-Oriented Research Career Development Award (K23) with the parent announcement labeled "Independent Clinical Trial Not Allowed."
When was this opportunity created, and how long is it open?
The opportunity was created on April 9, 2024. It remains open with an original closing date of May 7, 2027.
Is there an award ceiling listed for this opportunity?
An "Award Ceiling" field is referenced, but no specific ceiling amount is stated in the provided information.
Is the expected number of awards provided?
No. The number of expected awards is not specified in the provided information, which is noted as common for parent NIH announcements because award counts and budgets can vary by institute, fiscal year, and application volume.
What kinds of organizations are eligible to apply?
Eligibility is broad at the organizational level and includes: state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses.
Are certain institution types explicitly highlighted as eligible?
Yes. The announcement explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply directly?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all under this opportunity?
Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. This means certain internationally performed activities may be permissible when they meet NIH policy requirements and are justified within the scope of an otherwise eligible U.S.-based application.
How should applicants think about institute- or center-specific guidance?
The provided information indicates applicants typically need to ensure their project fits NIH rules for this funding opportunity and aligns with any additional institute- or center-specific guidance, especially when interventional elements, ancillary studies, or connections to existing trials might be involved.
What is the overall "best fit" for this K23 opportunity?
This opportunity is best understood as a mentored career development pathway for clinically trained professionals who want to specialize in patient-oriented research. The emphasis is on mentorship, training, and research support while developing into an independent clinician-scientist, rather than launching an independently run clinical trial as the central feature of the award.
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| Funding Opportunity |
|---|
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) Apply for PA 24 184 Funding Number: PA 24 184 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required) Apply for PA 24 190 Funding Number: PA 24 190 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed) Apply for PA 24 191 Funding Number: PA 24 191 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 24 175 Funding Number: PA 24 175 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 24 176 Funding Number: PA 24 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) Apply for PA 24 182 Funding Number: PA 24 182 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) Apply for PA 24 193 Funding Number: PA 24 193 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) Apply for PA 24 194 Funding Number: PA 24 194 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) Apply for PAR 24 131 Funding Number: PAR 24 131 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 24 152 Funding Number: PAR 24 152 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $375,000 |
| PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 24 247 Funding Number: PA 24 247 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 24 245 Funding Number: PA 24 245 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 24 246 Funding Number: PA 24 246 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) Apply for PA 24 254 Funding Number: PA 24 254 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) Apply for RFA OD 24 011 Funding Number: RFA OD 24 011 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed) Apply for RFA OD 24 010 Funding Number: RFA OD 24 010 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Required) Apply for PAR 24 226 Funding Number: PAR 24 226 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 24 225 Funding Number: PAR 24 225 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Database (UM1) Apply for RFA RM 15 016 Funding Number: RFA RM 15 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Apply for RFA RM 15 017 Funding Number: RFA RM 15 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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