Opportunity Information: Apply for RFA DK 27 112
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), is planning to fund a single cooperative agreement (U01) to continue the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center. EDIC is the long-running follow-up study to the landmark Diabetes Control and Complications Trial (DCCT), and this opportunity is meant to keep the EDIC cohort under active observation so researchers can keep learning how type 1 diabetes complications develop and progress over time. The NOFO is specifically framed as a single-source competition, meaning NIH intends to invite an application from the eligible organization(s) identified in the eligibility section of the formal announcement, rather than opening the competition broadly to all applicants. Even though it is single-source, the application will still go through standard NIH peer review, and only applications judged to be scientifically strong and programmatically appropriate will be considered for an award.
The scientific goal is continuation and enhancement of EDIC as a uniquely valuable longitudinal cohort for understanding complications of type 1 diabetes. NIDDK is looking for a collaborative research center that can both maintain the cohort infrastructure and propose hypothesis-driven research that fills clearly defined knowledge gaps related to the onset, progression, and mechanisms of diabetes complications. In practical terms, the funded center is expected to support the ongoing operations needed to keep EDIC functioning as a high-quality, long-term study: continued participant follow-up, standardized data collection, and stewardship of the study resources that make EDIC so useful to the broader research community. The NOFO also emphasizes leveraging the EDIC dataset along with associated biologic and genetic samples, signaling that proposals should not just preserve the cohort, but actively use its deep longitudinal phenotyping and biospecimen resources to answer important scientific questions.
From an administrative and project-structure standpoint, the award mechanism is a cooperative agreement (U01), which typically means NIH expects substantial programmatic involvement during the life of the award compared with a standard research project grant. The NOFO also clearly states "Clinical Trial Not Allowed," indicating the funded activities should not be structured as a prospective clinical trial that assigns participants to interventions. Instead, the focus is on observational follow-up, cohort maintenance, and research analyses and ancillary studies that fit within the EDIC cohort framework without constituting a new clinical trial.
Key opportunity details provided include the funding opportunity number RFA-DK-27-112 and the title "Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)." The activity category is health (CFDA 93.847), the instrument type is a cooperative agreement, and NIH anticipates making one award. The original closing date listed is 2026-11-09. An award ceiling is not specified in the provided text, which often means applicants must rely on the full NOFO for budget expectations or any institute guidance on allowable costs and scope.
Eligibility and international collaboration rules are a major part of this announcement. Non-U.S. (foreign) organizations are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. At the same time, the NOFO allows "foreign components" as defined by the NIH Grants Policy Statement, which generally refers to discrete elements of a project conducted outside the United States that are integral to the project. However, the NOFO draws a firm line against foreign subawards or subcontracts: NIH states it will no longer issue awards that involve foreign subawards/subcontracts unless the application is submitted under a NOFO specifically designed for funded international collaborations. As a result, any application to this NOFO that includes foreign subawards/subcontracts will be considered noncompliant and will not be reviewed for funding. The policy does not prohibit unfunded international collaborations, the use of foreign consultants in allowable ways, or purchasing unique equipment or supplies from foreign vendors, but it does prohibit sending award funds to foreign institutions through subawards or subcontracts under this particular funding opportunity.
Overall, this NOFO is best understood as a continuation funding action designed to preserve and further capitalize on one of the most important long-term type 1 diabetes cohorts in the world. NIDDK is signaling that EDIC remains a cornerstone resource for complication research and wants a single research center award that can keep the cohort strong operationally while also producing high-value, hypothesis-based science that addresses specific gaps in what is known about how type 1 diabetes complications emerge and evolve across the lifespan.Apply for RFA DK 27 112
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2026-08-31.
- Applicants must submit their applications by 2026-11-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQ)
What is this funding opportunity?
This is an NIH/NIDDK funding opportunity to support the continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center through a single cooperative agreement award (U01). EDIC is the long-term follow-up study to the Diabetes Control and Complications Trial (DCCT).
Which NIH Institute is offering this opportunity?
The opportunity is offered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which is part of the National Institutes of Health (NIH).
What is the funding opportunity number and title?
Funding opportunity number: RFA-DK-27-112.
Title: "Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)."
What is EDIC, and why is it important?
EDIC is a long-running longitudinal cohort study that follows participants from the landmark DCCT to understand how complications of type 1 diabetes develop and progress over time. This opportunity aims to keep the EDIC cohort under active observation so the research community can continue learning from its long-term follow-up, standardized data collection, and associated biologic and genetic resources.
What is the main purpose of this award?
The purpose is to continue and enhance EDIC as a uniquely valuable longitudinal cohort for understanding the onset, progression, and mechanisms of type 1 diabetes complications. The funded center is expected to maintain cohort infrastructure and also conduct hypothesis-driven research to address clearly defined knowledge gaps related to diabetes complications.
How many awards does NIH anticipate making?
NIH anticipates making one award.
What does "single-source competition" mean in this NOFO?
This NOFO is framed as a single-source competition, meaning NIH intends to invite an application from the eligible organization(s) identified in the eligibility section of the formal announcement rather than opening the competition broadly to all applicants.
If it is single-source, will the application still be peer reviewed?
Yes. Even though the competition is single-source, the application will still go through standard NIH peer review. Only applications judged to be scientifically strong and programmatically appropriate will be considered for an award.
What grant mechanism is being used?
The award mechanism is a cooperative agreement (U01).
What does a cooperative agreement (U01) imply for project oversight?
A U01 cooperative agreement typically means NIH expects substantial programmatic involvement during the life of the award compared with a standard research project grant.
Is this opportunity considered a clinical trial?
No. The NOFO explicitly states "Clinical Trial Not Allowed."
What does "Clinical Trial Not Allowed" mean for the proposed work?
It means the funded activities should not be structured as a prospective clinical trial that assigns participants to interventions. The focus is on observational follow-up, cohort maintenance, and research analyses and ancillary studies that fit within the EDIC cohort framework without constituting a new clinical trial.
What kinds of activities is the funded EDIC Research Center expected to support?
Based on the information provided, the center is expected to support ongoing operations to keep EDIC functioning as a high-quality long-term study, including continued participant follow-up, standardized data collection, and stewardship of study resources. The center is also expected to propose and conduct hypothesis-driven research that leverages EDIC data and associated biologic and genetic samples.
How does NIDDK want applicants to use the EDIC dataset and samples?
The NOFO emphasizes leveraging the EDIC dataset along with associated biologic and genetic samples. This signals that proposals should not only preserve the cohort infrastructure, but also actively use EDIC's deep longitudinal phenotyping and biospecimen resources to answer important scientific questions.
What scientific areas should the proposed research address?
The research should fill clearly defined knowledge gaps related to the onset, progression, and mechanisms of type 1 diabetes complications, using EDIC as the underlying cohort resource.
What is the activity category and assistance listing (CFDA) number?
The activity category is health, and the CFDA/Assistance Listing number provided is 93.847.
What is the application closing date?
The original closing date listed is 2026-11-09.
Is an award ceiling or budget maximum provided in the information?
No award ceiling is specified in the provided text. This often means applicants must rely on the full NOFO for budget expectations or any institute guidance on allowable costs and scope.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-U.S. (foreign) organizations are not eligible to apply under this NOFO.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are also not eligible to apply.
Does the NOFO allow any foreign involvement at all?
Yes, the NOFO allows "foreign components" as defined by the NIH Grants Policy Statement, generally meaning discrete elements of a project conducted outside the United States that are integral to the project.
Are foreign subawards or subcontracts allowed?
No. NIH states it will no longer issue awards that involve foreign subawards/subcontracts unless the application is submitted under a NOFO specifically designed for funded international collaborations. For this NOFO, any application that includes foreign subawards/subcontracts will be considered noncompliant and will not be reviewed for funding.
What happens if an application includes a foreign subaward or foreign subcontract?
It will be considered noncompliant and will not be reviewed for funding under this NOFO.
Are unfunded international collaborations prohibited?
No. The policy described does not prohibit unfunded international collaborations.
Are foreign consultants allowed?
The information provided indicates the policy does not prohibit the use of foreign consultants in allowable ways.
Can the project purchase unique equipment or supplies from foreign vendors?
Yes. The information provided indicates the policy does not prohibit purchasing unique equipment or supplies from foreign vendors.
What is the overall intent of this NOFO in plain terms?
This is a continuation funding action designed to preserve and further capitalize on EDIC as a cornerstone long-term type 1 diabetes cohort. NIDDK is seeking a single research center award that can keep the cohort strong operationally while producing high-value, hypothesis-based science about how complications emerge and evolve over time.
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