Opportunity Information: Apply for PAR 18 771
The NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22, Clinical Trial Required) is a National Institutes of Health grant opportunity designed specifically to help highly qualified postdoctoral fellows and research trainees working in the NHLBI Division of Intramural Research move from a mentored intramural training environment into an independent, faculty-style research position at an extramural institution. In practical terms, the program is meant to bridge the common gap between strong postdoctoral work at NIH and the launch of an independent research program elsewhere, giving investigators both time and structured support to build a publishable body of work, define a coherent research direction, and then establish that program at a university or other eligible US-based research organization. Because the FOA is labeled "Clinical Trial Required," applicants are expected to propose research that includes a clinical trial component consistent with NIH definitions and the specific requirements laid out in the full announcement.
The award is structured in two connected phases totaling up to five years of support. The first phase is a mentored intramural phase that can last up to two years while the investigator remains within NHLBI intramural research. This period is intended for intensive mentored development and productivity: completing key experiments, generating preliminary data, publishing, and shaping an independent research niche that can be carried forward. The second phase is an extramural phase that can last three years and takes place after the awardee secures an independent position at an eligible extramural institution. This extramural portion is intended to help the awardee establish their lab or research program, continue the proposed line of work, and build momentum toward longer-term independent funding.
A key feature of this K22 is that the move from the intramural phase to the extramural phase is not automatic. The transition requires NHLBI approval and is contingent on demonstrated progress during the mentored phase. NHLBI conducts a progress review that evaluates the success of the intramural research and also examines the proposed research plan for the extramural institution. That review functions as a go/no-go checkpoint, ensuring that the candidate has achieved sufficient scientific and professional development and that the planned extramural work is strong, feasible, and well-matched to the new independent setting. In other words, the award is designed to support a transition, but the applicant must earn that transition through performance and a convincing forward plan.
Eligibility is limited and notably excludes foreign participation. Non-domestic (non-US) entities (foreign institutions) are not eligible to apply, and non-domestic components of US organizations are also not eligible. In addition, foreign components as defined by the NIH Grants Policy Statement are not allowed under this opportunity. The eligible applicant type listed includes public and state-controlled institutions of higher education, reflecting the expectation that the extramural phase will be conducted at a qualifying US-based institution. The sponsoring agency is the National Institutes of Health, and the funding activity falls under health-related research categories, with CFDA numbers listed as 93.233 and 93.837 through 93.840. The opportunity number is PAR-18-771, created on 2018-05-09, with an original closing date shown as 2021-05-07. The public summary does not provide an award ceiling or expected number of awards, so those details would need to be confirmed in the full FOA text or related NHLBI guidance.
Overall, this K22 mechanism is best understood as a structured career launch program for NHLBI intramural trainees who are ready to move toward independence. It offers a defined runway: first, mentored support to solidify a competitive research package inside NHLBI, and second, time-limited extramural funding to help convert that package into a sustainable independent program. The built-in progress review and required approval for transition underscore that the award is performance-based, with continued support tied to clear research advancement and a credible plan for the independent phase.Apply for PAR 18 771
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on 2018-05-09.
- Applicants must submit their applications by 2021-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQ)
What is the NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22, Clinical Trial Required)?
This opportunity is an NIH/NHLBI career development award designed to help highly qualified postdoctoral fellows and research trainees in the NHLBI Division of Intramural Research transition from a mentored intramural training environment into an independent, faculty-style research position at an eligible extramural institution in the United States. The intent is to bridge the gap between strong postdoctoral work at NIH and launching an independent research program elsewhere.
Who is this K22 intended for?
It is intended specifically for postdoctoral fellows and research trainees working within the NHLBI Division of Intramural Research who are preparing to move to independence at an extramural institution. The program is framed as a structured career launch mechanism for intramural trainees ready to define and carry forward an independent research direction.
What does "Clinical Trial Required" mean for applicants?
The funding opportunity is labeled "Clinical Trial Required," which means applicants are expected to propose research that includes a clinical trial component consistent with NIH definitions and the specific requirements described in the full funding opportunity announcement (FOA). The proposed work is expected to include a clinical trial element rather than being purely non-clinical-trial research.
How is the award structured?
The award has two connected phases that together provide up to five years of support. It starts with a mentored intramural phase (up to two years) within NHLBI intramural research, followed by an extramural phase (up to three years) after the awardee secures an independent position at an eligible extramural institution.
How long is the intramural (mentored) phase, and what is it for?
The mentored intramural phase can last up to two years while the investigator remains in the NHLBI intramural research environment. This phase is intended for intensive mentored development and productivity, including completing key experiments, generating preliminary data, publishing, and shaping a coherent independent research niche that can be carried forward to the extramural institution.
How long is the extramural phase, and what is it for?
The extramural phase can last up to three years and occurs after the awardee has secured an independent position at an eligible extramural institution. This phase is meant to support establishment of the awardee's lab or research program, continuation of the proposed research line, and momentum-building toward longer-term independent funding.
Is the transition from the intramural phase to the extramural phase automatic?
No. The transition is not automatic. Moving from the intramural phase to the extramural phase requires NHLBI approval and depends on demonstrated progress during the mentored phase.
What does NHLBI evaluate before approving the transition to the extramural phase?
NHLBI conducts a progress review that evaluates (1) success of the intramural research during the mentored phase and (2) the proposed research plan to be carried out at the extramural institution. This review functions as a go/no-go checkpoint to confirm that the candidate has achieved sufficient scientific and professional development and that the extramural plan is strong, feasible, and appropriate for the new independent setting.
What are the eligibility limitations related to foreign institutions or foreign components?
Foreign participation is excluded. Non-domestic (non-US) entities (foreign institutions) are not eligible to apply, non-domestic components of US organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed under this opportunity.
What types of institutions are listed as eligible applicants for the extramural phase?
The eligible applicant type listed includes public and state-controlled institutions of higher education, reflecting the expectation that the extramural phase will be conducted at a qualifying US-based institution.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), with the program administered through the National Heart, Lung, and Blood Institute (NHLBI).
What is the opportunity number for this FOA?
The opportunity number is PAR-18-771.
When was this opportunity created, and what is the closing date shown in the summary?
The opportunity was created on 2018-05-09, and the original closing date shown in the summary is 2021-05-07.
Are the award ceiling and the expected number of awards provided in the summary?
No. The public summary does not provide an award ceiling or the expected number of awards. Those details would need to be confirmed in the full FOA text or related NHLBI guidance.
What are the CFDA numbers associated with this opportunity?
The summary lists CFDA numbers 93.233 and 93.837 through 93.840.
What is the main goal of this K22 mechanism in practical terms?
In practical terms, the goal is to bridge the common gap between NIH intramural postdoctoral training and the launch of an independent research program at an extramural institution by providing time and structured support to build a publishable body of work, define a coherent research direction, and then establish that program in an independent setting.
What does "performance-based" support mean in the context of this award?
It means continued support into the extramural phase is tied to clear advancement during the intramural mentored period and a credible, well-matched research plan for the independent phase. The progress review and required NHLBI approval are built-in mechanisms to ensure the transition is earned through progress and readiness.
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