Limited Competition: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) (U24 Clinical Trial Not Allowed) | RFA HG 22 020

Opportunity Information: Apply for RFA HG 22 020

This funding opportunity, RFA-HG-22-020, is a National Institutes of Health (NIH) notice from the National Human Genome Research Institute (NHGRI) to support the ongoing development, operation, and user-facing support of the Genomic Data Science Analysis, Visualization, and Informatics Lab-space, commonly referred to as AnVIL. The award mechanism is a U24 cooperative agreement in the health category (CFDA 93.172), which typically means the funded project is expected to be a substantial, service-oriented scientific resource and that NIH program staff will have an active role in coordinating priorities, milestones, and oversight. Clinical trials are not allowed under this announcement, so the work is intended to focus on infrastructure, platforms, tools, operations, and support rather than testing clinical interventions.

At its core, the opportunity is about sustaining and improving AnVIL as a scalable, interoperable, cloud-based environment that helps the basic and clinical genomics research communities analyze, visualize, and share data. The emphasis is on “democratizing” access to data and computation, meaning that researchers should be able to work with very large genomic and genomics-related datasets without needing to download massive files locally or maintain expensive on-premises computing systems. By relying on cloud infrastructure, AnVIL is positioned to bring computing to the data, enable collaborative analysis, and support standardized workflows and tools that can be reused across studies and institutions.

The scope described in the announcement centers on three broad deliverables: continued development (building or improving platform capabilities and interoperable components), maintenance (keeping the resource stable, secure, and up to date as technologies and user needs evolve), and user support (helping the research community actually adopt and effectively use the platform). In practical terms, “user support” in a resource like this often implies documentation, training materials, help desk functions, onboarding assistance, and community engagement, so the platform is not just technically functional but also usable and accessible to a wide range of investigators.

A key feature of this notice is that it is a limited competition. Eligibility is restricted to recipient organizations that were funded under the earlier solicitation RFA-HG-17-011, which means only a defined set of organizations already involved in the prior phase of this effort can apply. The posting also lists various categories of entities that NIH commonly recognizes as eligible applicant types (for example, public and private higher education institutions, nonprofits, for-profits, small businesses, and governmental units), and it explicitly highlights additional institution types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, tribal governments (including those other than federally recognized), U.S. territories or possessions, foreign organizations, and regional organizations. Even with those broad categories mentioned, the limited-competition restriction tied to RFA-HG-17-011 is the controlling eligibility condition for this specific RFA.

Administrative details provided include the original closing date of December 2, 2022, and the funding instrument type as a cooperative agreement. The announcement does not state an award ceiling or expected number of awards in the excerpt provided, but the intent is clearly to fund resource-level work to keep AnVIL functioning as a national genomics data science platform. Overall, the opportunity is aimed at ensuring AnVIL remains a robust, cloud-based ecosystem where genomic researchers can securely access large datasets, run scalable analyses, visualize results, and collaborate efficiently, with ongoing technical stewardship and responsive user support under NHGRI guidance.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2022-09-14.
• Applicants must submit their applications by 2022-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HG 22 020

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